Sequence of joint tissue inflammation during rheumatoid arthritis development
نویسندگان
چکیده
منابع مشابه
Radioisotope study of small joint inflammation in rheumatoid arthritis.
Radioactive technetium (9QmTc), introduced into nuclear medicine in 1964 (Harper, Beck, Charleston, and Lathrop, 1964), has been used to visualize many organs (McCready, 1967), including the thyroid gland (Andros, Harper, Lathrop, and McCardle, 1965), the salivary glands (Harden, Hilditch, Kennedy, Mason, Papadopoulos, and Alexander, 1967b), the stomach (Harden, Alexander, and Kennedy, 1967a; I...
متن کاملBiochemical markers of joint tissue turnover in early rheumatoid arthritis.
The progression of rheumatoid arthritis (RA), a disease characterized by synovitis, cartilage degradation and bone erosion, is highly variable from patient to patient. New specific biological markers reflecting quantitative and dynamic changes in joint tissue turnover have been recently developed and include assays for type II collagen synthesis and degradation and synovitis. Increasing evidenc...
متن کاملSynovial tissue macrophages and joint erosion in rheumatoid arthritis.
OBJECTIVES To analyse the mononuclear cell populations in synovial membrane biopsies obtained before treatment from patients with rheumatoid arthritis (RA) and to correlate the findings with the degree of joint damage occurring over one year. METHODS Multiple needle biopsy specimens were obtained from inflamed knee joints on entry to the study. The tissue samples were examined using immunohis...
متن کاملChanges in Glycosylation of Alpha-1-Protease Inhibitor in Inflammation (Rheumatoid Arthritis and Crohn\'s Disease)
Alpha-1-proteinase inhibitor (API) is one of the acute phase proteins. Following an inflammatory stimuli the concentration of API increased up to four folds. Accompanying these quantitative changes, there is qualitative alterations in the structure of carbohydrate moiety (glycosylation). To determine the alterations in the glycosylation of API in inflammation, API was isolated from the sera of...
متن کاملMetalloproteinases, inflammation, and rheumatoid arthritis.
Ideally, the inflammatory response occurs rapidly to terminate infection. It also must halt in a timely manner to stop this reaction from inflicting self damage. Such a highly regulated process results from altering balances in pro- and anti-inflammatory signals orchestrated by multiple cell types and factors within the tissue microenvironment. The discovery of new substrates of metalloproteina...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2018
ISSN: 1478-6362
DOI: 10.1186/s13075-018-1756-z